Review Questions: Final Exam
These questions cover only those 4 lectures that you have not yet been tested on; the
key is at the end. Also, be familiar with the general structure of antibody molecules.
Remember that the final has comprehensive elements – to study previously tested
material refer to the exams and review questions. Don’t forget to review the answer
keys for the old exams, including the answer sheets. I will stick to the same general
topics that I tested you on before, just don’t expect to see the same questions exactly (I
may use elements of them, however, so be sure to READ THE QUESTIONS
CAREFULLY).
1) The lowest concentration of an antibiotic that prevents growth is the
a) minimal inhibitory concentration (MIC).
b) minimal lethal concentration (MLC).
c) 50% inhibitory dose.
d) all of the above
2) In order to be effective, the concentration of a drug in the body must be
a) higher than the pathogen’s minimal inhibitory concentration (MIC).
b) lower than the pathogen’s MIC.
c) higher than the pathogen’s MLC.
d) lower than the pathogen’s MLC.
3) The ratio of toxic dose to therapeutic dose is called the
a) toxicity index.
b) phenol coefficient.
c) therapeutic index.
d) susceptibility quotient
4) Which of the following is (are) used by microorganisms to become resistant to a
particular drug?
a) enzymatic inactivation of the drug
b) exclusion of the drug from the cell
c) an alternate metabolic pathway that bypasses the drug-sensitive step
d) all of the above
5) Penicillin and its derivatives
a) inhibit the transglycosylase reaction in peptidoglycan biosynthesis.
b) interfere with the action of the lipid carrier that transports peptidoglycan
precursors across the plasma membrane.
c) inhibit the transpeptidation reaction in peptidoglycan biosynthesis.
d) block the addition of the pentapeptide chain during peptidoglycan biosynthesis.
6) T/F One way in which organisms may exhibit resistance to a drug is the ability to
pump the drug out of the cell immediately after it has entered.
