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Final Exam Review Questions - General Microbiology | BIOL 311, Study notes of Biology

Final Exam Review Material Type: Notes; Professor: Dawe; Class: GENERAL MICROBIOLOGY; Subject: BIOLOGY; University: New Mexico State University-Main Campus; Term: Fall 2010;

Typology: Study notes

2010/2011

Uploaded on 12/09/2011

dredre224
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Review Questions: Final Exam
These questions cover only those 4 lectures that you have not yet been tested on; the
key is at the end. Also, be familiar with the general structure of antibody molecules.
Remember that the final has comprehensive elements – to study previously tested
material refer to the exams and review questions. Don’t forget to review the answer
keys for the old exams, including the answer sheets. I will stick to the same general
topics that I tested you on before, just don’t expect to see the same questions exactly (I
may use elements of them, however, so be sure to READ THE QUESTIONS
CAREFULLY).
1) The lowest concentration of an antibiotic that prevents growth is the
a) minimal inhibitory concentration (MIC).
b) minimal lethal concentration (MLC).
c) 50% inhibitory dose.
d) all of the above
2) In order to be effective, the concentration of a drug in the body must be
a) higher than the pathogen’s minimal inhibitory concentration (MIC).
b) lower than the pathogen’s MIC.
c) higher than the pathogen’s MLC.
d) lower than the pathogen’s MLC.
3) The ratio of toxic dose to therapeutic dose is called the
a) toxicity index.
b) phenol coefficient.
c) therapeutic index.
d) susceptibility quotient
4) Which of the following is (are) used by microorganisms to become resistant to a
particular drug?
a) enzymatic inactivation of the drug
b) exclusion of the drug from the cell
c) an alternate metabolic pathway that bypasses the drug-sensitive step
d) all of the above
5) Penicillin and its derivatives
a) inhibit the transglycosylase reaction in peptidoglycan biosynthesis.
b) interfere with the action of the lipid carrier that transports peptidoglycan
precursors across the plasma membrane.
c) inhibit the transpeptidation reaction in peptidoglycan biosynthesis.
d) block the addition of the pentapeptide chain during peptidoglycan biosynthesis.
6) T/F One way in which organisms may exhibit resistance to a drug is the ability to
pump the drug out of the cell immediately after it has entered.
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These questions cover only those 4 lectures that you have not yet been tested on; the key is at the end. Also, be familiar with the general structure of antibody molecules. Remember that the final has comprehensive elements – to study previously tested material refer to the exams and review questions. Don’t forget to review the answer keys for the old exams, including the answer sheets. I will stick to the same general topics that I tested you on before, just don’t expect to see the same questions exactly (I may use elements of them, however, so be sure to READ THE QUESTIONS CAREFULLY).

  1. The lowest concentration of an antibiotic that prevents growth is the a) minimal inhibitory concentration (MIC). b) minimal lethal concentration (MLC). c) 50% inhibitory dose. d) all of the above
  2. In order to be effective, the concentration of a drug in the body must be a) higher than the pathogen’s minimal inhibitory concentration (MIC). b) lower than the pathogen’s MIC. c) higher than the pathogen’s MLC. d) lower than the pathogen’s MLC.
  3. The ratio of toxic dose to therapeutic dose is called the a) toxicity index. b) phenol coefficient. c) therapeutic index. d) susceptibility quotient
  4. Which of the following is (are) used by microorganisms to become resistant to a particular drug? a) enzymatic inactivation of the drug b) exclusion of the drug from the cell c) an alternate metabolic pathway that bypasses the drug-sensitive step d) all of the above
  5. Penicillin and its derivatives a) inhibit the transglycosylase reaction in peptidoglycan biosynthesis. b) interfere with the action of the lipid carrier that transports peptidoglycan precursors across the plasma membrane. c) inhibit the transpeptidation reaction in peptidoglycan biosynthesis. d) block the addition of the pentapeptide chain during peptidoglycan biosynthesis.
  6. T/F One way in which organisms may exhibit resistance to a drug is the ability to pump the drug out of the cell immediately after it has entered.
  1. Sulfanilamide is an analog of a) citric acid. b) p- aminobenzoic acid. c) folic acid. d) sulfuric acid.
  2. Primary targets for antibiotic action include a) the cell wall. b) Synthesis of essential compounds c) DNA replication and transcription. d) all of the above.
  3. The shortest period of time needed to kill all organisms in a sample at a specified temperature is the a) thermal death time (TDT). b) thermal death point (TDP). c) decimal reduction time ( d ). d) death value (D v ).
  4. Organisms that require Biological Safety Level 2 containment are those that a) present no risk b) are very infectious and have no known treatment c) are very infectious but treatment is available d) are infectious but are not airborne
  5. What is the “decimal reduction time”? a) one tenth of the time taken to kill all the bacteria in a sample at a defined temperature b) the time taken to reduce the number of viable bacteria in sample by 1/10 at a defined temperature c) the time taken to reduce the number of viable bacteria in sample by 90 % at a defined temperature d) 10 times the amount of time required to sterilize a sample
  6. An autoclave uses what kind of sterilization technique? a) moist heat from steam under pressure b) UV light c) Filtration d) Dry heat

Key:

  1. A
  2. A
  3. C
  4. D
  5. C
  6. T
  7. B
  8. D
  9. A
  10. D
  11. C
  12. A
  13. B
  14. D
  15. F
  16. A