Docsity
Log inSign up
Docsity
Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity

Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan

Guidelines and tips
Guidelines and tips
Sell on Docsity
Sell on Docsity
Log inSign up

Prepare for your exams

Study with the several resources on Docsity

Find documents

Prepare for your exams with the study notes shared by other students like you on Docsity

Search Store documents

The best documents sold by students who completed their studies

Search through all study resources
Docsity AINEW

Summarize your documents, ask them questions, convert them into quizzes and concept maps

Explore questions

Clear up your doubts by reading the answers to questions asked by your fellow students

Earn points to download

Earn points by helping other students or get them with a premium plan

Share documents
download point icon20 Points

For each uploaded document

Answer questions
download point icon5 Points

For each given answer (max 1 per day)

All the ways to get free points
Get points immediately

Choose a premium plan with all the points you need

Study Opportunities

Choose your next study program

Get in touch with the best universities in the world. Search through thousands of universities and official partners

Community

Ask the community

Ask the community for help and clear up your study doubts

University Rankings

Discover the best universities in your country according to Docsity users

Free resources

Our save-the-student-ebooks!

Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors

From our blog

Exams and Study
Go to the blog

Exam 2 with Answers | Immunology | BIOL 456, Exams of Immunology

University of New Mexico (UNM) - GallupImmunology

Material Type: Exam; Class: Immunology; Subject: Biology; University: University of New Mexico; Term: Fall 2015;

Typology: Exams

2014/2015
On special offer
30 Points
Discount

Limited-time offer

Uploaded on 11/10/2015

kimberly-allen1991
kimberly-allen1991 🇺🇸

5

(4)

4 documents

1 / 7

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
NAME:&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&
&EXAM&B&
!
!
1!
Immunology&456/556&&
Exam&2&&October&13th&2015&
!
Multiple!choice!questions!(2!points!each)!
!
1.!Terminal!!deoxynucleotidyl!transferase!(Tdt)!is!an!enzyme!that!
A)!Adds!P!nucleotides!to!the!coding!joints!
B)!Closes!the!hairpins!of!the!signal!joints!
C)!Adds!N!nucleotides!to!the!coding!joints!
D)!All!of!the!above!
!
2.!HLAIDM!is!
A) Encoded!within!the!MHC!
B) Upregulated!by!interferon!
C) Vital!for!peptide!editing!
D) All!of!the!above!
3.!IgD!!
A)!Is!expressed!on!the!surface!of!mature!naïve!B!cells!
B)!Is!expressed!following!class!switching!from!IgM!
C)!Is!present!in!high!amounts!in!serum!
D)!None!of!the!above!
!
4.!The!immunoproteasome:!
A) Is!induced!by!bacterial!PAMPs!
B) Is!induced!by!interferon!
C) Is!induced!by!adhesion!molecules!
D) Is!induced!by!interleukins!
5.!If!an!immature!B!cell!recognizes!a!multivalent!self!molecule!in!the!bone!marrow,!
the!B!cells!undergoes:!
A) Anergy!
B) Apoptosis!!
C) Clonal!deletion!or!receptor!editing!
D) Clonal!expansion!
6.!A!deficiency!in!any!of!the!enzymes!of!the!VDJ!recombinase!complex!results!in!
A)!Leukocyte!adhesion!deficiency!
B)!Chronic!granulomatous!diseases!
C)!Severe!combined!immunodeficiency!
D)!Autoimmune!disease!
!
7.!The!Switch!regions!!
A) Are!found!within!the!exons!of!all!IgH!genes!
B) Are!recognized!by!the!enzyme!TdT!
C) Are!recognized!by!the!enzyme!AID!
pf3
pf4
pf5
Discount

On special offer

Partial preview of the text

Download Exam 2 with Answers | Immunology | BIOL 456 and more Exams Immunology in PDF only on Docsity!

EXAM B

Immunology 456/ Exam 2 October 13th^2015 Multiple choice questions (2 points each)

  1. Terminal deoxynucleotidyl transferase (Tdt) is an enzyme that A) Adds P nucleotides to the coding joints B) Closes the hairpins of the signal joints C) Adds N nucleotides to the coding joints D) All of the above
  2. HLA-­‐DM is A) Encoded within the MHC B) Upregulated by interferon C) Vital for peptide editing D) All of the above
  3. IgD A) Is expressed on the surface of mature naïve B cells B) Is expressed following class switching from IgM C) Is present in high amounts in serum D) None of the above
  4. The immunoproteasome: A) Is induced by bacterial PAMPs B) Is induced by interferon C) Is induced by adhesion molecules D) Is induced by interleukins
  5. If an immature B cell recognizes a multivalent self molecule in the bone marrow, the B cells undergoes: A) Anergy B) Apoptosis C) Clonal deletion or receptor editing D) Clonal expansion
  6. A deficiency in any of the enzymes of the VDJ recombinase complex results in A) Leukocyte adhesion deficiency B) Chronic granulomatous diseases C) Severe combined immunodeficiency D) Autoimmune disease
  7. The Switch regions A) Are found within the exons of all IgH genes B) Are recognized by the enzyme TdT C) Are recognized by the enzyme AID

EXAM B

D) Are found in the V segments of light chains and heavy chains

  1. Monoclonal antibodies are produced in mice using A) The fusion technology B) Hybridoma production and selection technology C) Viral infection D) Irradiation technology
  2. The exogenous pathway of antigen presentation is A) Performed by every cell of the body B) Performed via MHC-­‐I molecules C) Performed by antigen presenting cells D) Dedicated to antigens synthesized by the cell
  3. The antigen binding site is composed by A) The framework regions of the C domains B) The hypervariable regions of the V domain of the light chain C) The hypervariable regions of the V domains of the light and heavy chain D) The Fc and hinge regions of the antibody
  4. The secondary diversification of the antibody repertoire is: A) Dependent on AID B) Restricted to T cells C) A feature of the bone marrow and thymus D) Dependent on TdT
  5. Allelic exclusion is: A) A process that prevents expression of more than one heavy chain type on the surface of B cells B) A process that prevents expression of more than one light chain type on the surface of B cells C) Reinforced by the expression of the surrogate light chain D) All of the above
  6. Secreted and membrane bound forms of immunoglobulins are produced by A) Class switch B) VDJ recombination C) Alternative splicing D) TdT
  7. If a viral protein interferes with tapasin: A) The virus will be presented via MHC class-­‐II B) TAP will not bind the peptide loading complex C) Cross presentation will be induced D) The immunoproteasome will not cleave antigens properly

EXAM B

C) Papain and pepsin digestions D) Papain, pepsin and mercaptoethanol digestions

  1. VDJ recombination: A) Takes place in primary lymphoid organs B) Takes place in B and T cells C) Takes place in the absence of antigen D) All of the above
  2. Lambda 5 is: A) Part of the surrogate light chain B) Similar to the V domain of a light chain C) Expressed in mature B cells D) All of the above
  3. One MHC class I molecule: A) Can only present one specific peptide B) Can only present a peptide of between 8-­‐10 amino acids C) Can only present a peptide with a hydrophilic C-­‐terminus D) Can present self and non-­‐self peptides at the same time
  4. Somatic hypermutation: A) Occurs in B and T cells B) Occurs in the bone marrow C) Is mediated by RAG genes D) None of the above
  5. Superantigens: A) Induce immediate strong immune responses B) Activate between 2-­‐ 2 0% of all T cells C) Do not required processing to bind to MHC D) All of the above
  6. Cytotoxic lymphocyte activity: A) Can be measured by western blot B) Can be measured by PCR C) Is measured by the chromium 51 release assay D) Is measured by the thymidine accumulation assay
  7. Antibody flexibility is conferred by A) The Fc B) The coding joints C) The hinge region D) The V domain
  8. The two immunoglobulin isotypes that can form multimers are A) IgA and IgD

EXAM B

B) IgA and IgM C) IgE and IgG D) IgG and IgM Short Answer

  1. Label the figure below (10 labels, 1 point each, 10 points total)
    1. Ag binding site
    2. VH
    3. CH
    4. VL
    5. CL
    6. Disulfide bonds
    7. Hinge region
    8. Fab
    9. Fc
    10. Fab’ 2

EXAM B

  1. Briefly explain the main events that take place from the moment a cell becomes infected with a virus until it gets killed by a cell of the immune system. Include the names of the cells and pathways that are involved in each step. Be thorough and think about each step, recognition, early signaling events, antigen processing, antigen presentation and how that leads to killing. You needed to have something along these lines. TLR3 activation (recognition of PAMP via PRR) à NFkB expression à Interferon production à induction of immunoproteasome (increased peptide processing) à increased MHC class I expression (increased peptide presentation) à recognition of antigenic peptide by CD8+ CTLs à induced killing of infection cell