Divine Intervention Episode 15
Metabolism Review B
Some MS4
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Metabolism Review: Dogma, Fructose Absorption, Lactose Intolerance, and FA Synthesis, Slides of Enzymes and Metabolism
An in-depth review of various aspects of metabolism, including the central dogma, fructose absorption, lactose intolerance, and fatty acid synthesis. Topics covered include the role of kinases, microbe destruction in lysosomes, and the regulation of glycolysis and glucokinase. Relevant clinical conditions, such as diabetes and urea cycle disorders, are also discussed.
Typology: Slides
2021/2022
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Download Metabolism Review: Dogma, Fructose Absorption, Lactose Intolerance, and FA Synthesis and more Slides Enzymes and Metabolism in PDF only on Docsity!
Divine Intervention Episode 15
Metabolism Review B
Some MS
Intro
The “Central Dogma” of
Metabolism.
Galactose Metabolism
Fructose Metabolism
Discussion of microbe destruction in lysosomes of macrophages after phagocytosis by the respiratory burst. ALS relationship. AML relationship. Reducing oxidative stress with Glutathione. Essential pathway to providing reducing power for cells. Treating CGD. Acetaminophen toxicity and rescue agent. The many “roles” of this rescue agent.
How does INH cause seizures (mechanism). The T1DM association. How does the urea cycle relate to NO synthesis? Patient with recurrent episodes of bronchospasm, flushing, and diarrhea presents with new onset memory loss and a diffuse body rash. A holosystolic murmur is heard at the LLSB. Associated valvular lesions. Common principle in hydroxylation reactions.
5B-Glucokinase vs. Hexokinase
-Hexokinase has a low KM and VMAX.
-Glucokinase has a high KM and VMAX.
Glucokinase is also induced by insulin.
Glucokinase is regulated by a regulatory
protein under the auspices of F-6-P and
glucose. MODY is assoc. w/GK mutations.
5G-Some Other Important Stuff -Pyruvate kinase is also regulated by phosphorylation and dephosphorylation. -Overall, glycolysis gives rise to the rule of 2s (2 ATPs, 2 NADH, and 2 Pyruvates). Pyruvate has multiple fates; -It can form lactate under the action of lactate DH. This step regenerates NAD to keep the Glyceraldehyde-3-P DH step working. -Pyruvate can go into mitochondria to receive special attention from the PDH complex ultimately leading to Acetyl-coA formation. -Pyruvate can receive special attention from Pyruvate carboxylase (what is a HY cofactor utilized by this enzyme???) to form OAA that can reverse course in gluconeogenesis (through subsequent PEPCK action).
6A-GLUT Transporters