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Cutaneous Drug Reaction -Key Points, Study notes of Dermatology

Cutaneous drug reaction is an important topic to be known both for practice and exams. This study notes help you to have a thorough and strong understanding on cutaneous drug reactions.

Typology: Study notes

2017/2018

Available from 02/28/2023

Drhope
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CUTANEOUS DRUG REACTIONS
MACULOPAPULAR
Also known as exanthematous drug reaction
Most common type
VESICULOBULLOUS
Can mimic pemphigus and porphyria.
ERYTHEMA MULTIFORMAE
Characteristic feature is Iris lesion or target lesion
Iris lesion present with a central area of vesicle or Purpura, a mid zone of edema, and an outer
ring of erythema
Lesions are on dorsum of hands, palms and extensor aspect of extremities.
STEVENS- JOHNSON SYNDROME
Serious drug reaction with constitutional symptoms like fever followed by maculopapular rash,
vesicles and bullae involving the trunk and limbs
Eyes oral cavity and genitals are involved
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CUTANEOUS DRUG REACTIONS

MACULOPAPULAR

 Also known as exanthematous drug reaction  Most common type VESICULOBULLOUS  Can mimic pemphigus and porphyria. ERYTHEMA MULTIFORMAE  Characteristic feature is Iris lesion or target lesion  Iris lesion present with a central area of vesicle or Purpura, a mid zone of edema, and an outer ring of erythema  Lesions are on dorsum of hands, palms and extensor aspect of extremities. STEVENS- JOHNSON SYNDROME  Serious drug reaction with constitutional symptoms like fever followed by maculopapular rash, vesicles and bullae involving the trunk and limbs  Eyes oral cavity and genitals are involved

TOXIC EPIDERMAL NECROLYSIS (TEN)

 Dermatological emergency with^ high mortality  Patient first presents with high grade fever and severe toxemia followed by purpuric macules on the trunk and limbs with a charred appearance  The lesions are soon followed by blistering and large areas of the skin sloughs off leading to extensive areas of erosions  Severe oral, eye and genital involvement EXFOLIATIVE DRUG ERUPTION  Heavy metals, ayurevdic and homoeopathic preparations are notorious to cause this type of drug reactions. FIXED DRUG ERUPTION