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The recent change in the number of doses per vial of Pfizer-BioNTech COVID-19 vaccine from 5 to 6, and the methods to effectively withdraw 6 doses using low dead volume syringes. It also explains the concept of low dead volume syringes and their importance in minimizing vaccine wastage.
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Change in doses per vial of Pfizer-BioNTech vaccine
Low Dead Volume Syringes Low Dead Volume (also called low dead-space) is the amount of fluid remaining within the syringe and needle after injection is completed 4 In the absence of the LDV syringes a regular 1ml syringe or a 3 ml syringe is still usable. Vaccine should not be withheld in the absence of the LDV syringes Figure from Zule et al Harm Reduction Journal (2018)
Process to Assess the Dead Volume of a Syringe: Based on ISO 7886 Annex C^5 Fill up whole volume with water Weigh Empty Syringe (A) Empty water Reweigh syringe (B) Dead Volume = Reweighed Syringe – Empty Syringe (B) – (A)