A. Classical Biology- describes
relationships & processes of living
things
B. Bioinformatics- New Biology
C. Gene Expression Data
D. Homology Studies
XX. Bioinformatics
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Bioinformatics: Gene Expression Data and Homology Studies - Prof. Roman E. Boldyreff, Study notes of Biology
Information on bioinformatics, specifically focusing on gene expression data and homology studies. Gene expression data involves comparing the expression of several genes of a single organism in response to environmental stress, while homology studies compare nucleotide or amino acid sequences among species to determine relatedness. Fold change data and dendrograms for analyzing gene clusters and evolutionary relationships.
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A. Classical Biology- describes
relationships & processes of living
things
B. Bioinformatics- New Biology
C. Gene Expression Data
D. Homology Studies
XX. Bioinformatics
B. Bioinformatics
1. Use of computer data bases & programs to study biological information, particularly **amino acid & nucleotide sequences
- Computational Molecular Biology** (Bioinformatics) a. Genomics- genomes & gene sequences b. Proteomics- proteins & gene expression c. Metabolomics- products of protein mediated reactions & metabolic pathways
2. Fold Change Data
a. Log transformed ratios compared in
table to locate related gene clusters
gene 0hr 2hr 4hr 6hr 8hr 10hr
a 0 1.00 1.58 2.00 1.58 1. b 0 - 1.00 - 1.60 - 2.00 - 1.60 - 1. c 0 1.00 1.58 2.00 1.58 1.
D. Homology Studies
1. Compare nucleotide or amino acid sequences among species to determine **relatedness
- Comparative Genomics & Comparative** **Proteomics
- Biology Workbench & NCBI**
c. Phylogenetic Dendogram
1.) Ribosome small sub unit gene
2.) Data:
Comparison DNA Distance Canis latrans vs C. lupus 0. C. lupus vs C. familaris 0. C. latrans vs C. familaris 0.