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Appearance : characteristics between dense connective tissue and cartilage. Composition : 1. chondrocytes – small, spindle-shaped, similar to fibroblasts.
Typology: Summaries
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Department of Histology and Embryology, P.J. Šafárik University, Medical Faculty , Košice Cartilage : Sylabus for foreign students Author: RNDr. Marianna Danková, PhD. Revised by: prof. MUDr. Eva Mechírová, CSc.
Characteristic :
- supporting connective tissue
Function : - supports soft tissues
Composition :
A: CELLS : 1. chondrocytes - synthesize and secrete extracellular matrix
a) amorphous ground substance
b) fibrils – 1. collagen II – fibres are not formed, fibrils with diameter 20nm
- the cartilage matrix immediately surrounding each chondrocyte is rich in glycosaminoglycans and poor in collagen – territorial or capsular matrix (intense basophilia, metachromasia) - matrix located between the capsules – interrteritorial matrix
1- collagen fibrils (collagen type II ) 2 – hyaluronic acid 3 – link protein 4 – chondroitinsulfate - glycosaminoglycan 5 – core protein 6 - proteoglycan
2. Interstitial growth – mitotic division of preexisting chondrocytes 1.during early phases of cartilage formation
Regeneration by appositional growth from perichondrium; the chondroblasts from perichondrium invade the damaged area and generate new cartilage in extensively damaged areas the cartilage is replaced by dense connective tissue
Types of cartilage:
Incidence : articular surfaces, wall of large respiratory passages – larynx, trachea, bronchi, epiphyseal plate, ventral ends of ribs, embryonic temporary skeleton
Appearance : bluish-white, translucent
Composition :
1. chondrocytes
Incidence : intervertebral discs, symphysis pubis
Appearance : characteristics between dense connective tissue and cartilage
Composition :
1. chondrocytes – small, spindle-shaped, similar to fibroblasts arranged singly or in long rows 2. extracellular matrix – great number of collagen I fibers – acidophilic, amorphous matrix less abundant Perichondrium is not identifiable.