Call for Chapters: The Multifactorial Etiology of Congenital Heart Disease:
Insights from Teratology, Genetics, and Exposomics
https://www.igi-global.com/publish/call-for-papers/call-details/8727
Proposals Submission Deadline: May 4, 2025
Full Chapters Due: June 27, 2025
Submission Date: June 27, 2025
Introduction
Congenital Heart Disease (CHD) remains one of the most prevalent and challenging congenital anomalies, affecting approximately 1% of all
live births worldwide. The etiology of CHD is complex, involving an intricate interplay of genetic, environmental, and exposomic factors. This
book aims to provide a comprehensive exploration of the teratogenic, genetic, and exposomic influences on the development of both syndromic
and non-syndromic CHD, addressing existing knowledge gaps and presenting cutting-edge research in this rapidly evolving field.
The book will explore the historical perspective on CHD etiology, tracing the evolution of our understanding from purely genetic models to the
current multifactorial paradigm. A significant portion of the book will be dedicated to exploring the non-genetic factors underlying CHD. The
exposomic perspective on CHD development will be a key focus of the book, reflecting the growing recognition of the importance of
environmental influences on fetal cardiovascular development. The book will also delve into the complex genetic landscape of non-syndromic
CHD, while discussing monogenic models, genetic heterogeneity, and the emerging understanding of polygenic and oligogenic contributions to
CHD risk. The book chapters will present recent advances in high-resolution metabolomics and the integration of omics technologies,
highlighting their potential to uncover complex gene-environment interactions in CHD etiology. Contents will address the challenges and
opportunities in translating research findings into clinical practice, including the potential for personalized prevention and treatment
strategies based on individual genetic and exposomic profiles.
Recommended Topics
• Etiological distinction in Syndromic vs. non-syndromic CHD • Teratogenic Factors in CHD Development • Rubella, Alcohol, PAH, plastics,
VOCs, infection, radiation • Environmental Metabolism Disrupting Chemicals • Metabolic Memory: Focus on Mitochondrial Function •
Medication-induced CHD: Lithium, retinoic acid, and anticonvulsants • Environmental teratogens: Industrial, occupational exposure,
