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Drug-CYP Enzymes Interactions: A Comprehensive Overview, Quizzes of Pharmacology

Definitions and explanations of various drugs and their interactions with cytochrome p450 (cyp) enzymes. Topics include phenobarbital, st. John's wort, acetaminophen, isoniazid, ethanol, cimetidine, grapefruit juice, itraconazole, oral contraceptives, succinylcholine, and thiopurine methyltransferase. Understanding these interactions is crucial for healthcare professionals and patients to avoid adverse drug reactions.

Typology: Quizzes

2012/2013

Uploaded on 08/02/2013

cantwell77515
cantwell77515 🇺🇸

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TERM 1
phenobarbital
DEFINITION 1
A barbiturate (sedative hypnotic)often used for chronic
treatment of seizure disrodersperfect example of a drug
which "induces" the CYP liver enzymes
TERM 2
St. John's
Wort
DEFINITION 2
Wort is a medieval word for herb, claimed to be a useful
"natural" antidepressantCYP enzyme "inducer" which means
increases the removal of many drugs (birth control)
TERM 3
Acetaminophen
DEFINITION 3
safe over the counter analgesicdepletion of glutathione in
liver required for phase 2 biotransformation causes toxic
metabolite to build up and destroy the liver
TERM 4
isoniazid
DEFINITION 4
anti-tuberculosis drug which can lead to the peripheral
neuropathy in slow acetylators
TERM 5
ethanol
DEFINITION 5
example of a zero order elimination (APE)
pf3

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phenobarbital

A barbiturate (sedative hypnotic)often used for chronic treatment of seizure disrodersperfect example of a drug which "induces" the CYP liver enzymes TERM 2

St. John's

Wort

DEFINITION 2 Wort is a medieval word for herb, claimed to be a useful "natural" antidepressantCYP enzyme "inducer" which means increases the removal of many drugs (birth control) TERM 3

Acetaminophen

DEFINITION 3 safe over the counter analgesicdepletion of glutathione in liver required for phase 2 biotransformation causes toxic metabolite to build up and destroy the liver TERM 4

isoniazid

DEFINITION 4 anti-tuberculosis drug which can lead to the peripheral neuropathy in slow acetylators TERM 5

ethanol

DEFINITION 5 example of a zero order elimination (APE)

cimetidine

very popular OTC heart burn medicationpotent inhibitor of some CYP enzymes TERM 7

grapefruit juice

DEFINITION 7 inactivates CYP 3A4 which increases the plasma levels of a wide variety of drugs that can lead to toxicitygood example of a food-drug adverse drug interaction TERM 8

itraconazole (Sporanox)

DEFINITION 8 widely used antifungal drugpotent inhibitor of CYP enzymes which can lead to increased plasma levels of dozens ofdifferentdrugs TERM 9

oral contraceptives

DEFINITION 9 induce some CYP and inhibits other CYP TERM 10

succinylcholine

DEFINITION 10 fast acting muscle relaxant which requires acetylcholine esterase (AchE) for biotransformationgenetic polymorphisms in AchE can result in prolonged drug induced apnea