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Definitions and explanations of various drugs and their interactions with cytochrome p450 (cyp) enzymes. Topics include phenobarbital, st. John's wort, acetaminophen, isoniazid, ethanol, cimetidine, grapefruit juice, itraconazole, oral contraceptives, succinylcholine, and thiopurine methyltransferase. Understanding these interactions is crucial for healthcare professionals and patients to avoid adverse drug reactions.
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A barbiturate (sedative hypnotic)often used for chronic treatment of seizure disrodersperfect example of a drug which "induces" the CYP liver enzymes TERM 2
DEFINITION 2 Wort is a medieval word for herb, claimed to be a useful "natural" antidepressantCYP enzyme "inducer" which means increases the removal of many drugs (birth control) TERM 3
DEFINITION 3 safe over the counter analgesicdepletion of glutathione in liver required for phase 2 biotransformation causes toxic metabolite to build up and destroy the liver TERM 4
DEFINITION 4 anti-tuberculosis drug which can lead to the peripheral neuropathy in slow acetylators TERM 5
DEFINITION 5 example of a zero order elimination (APE)
very popular OTC heart burn medicationpotent inhibitor of some CYP enzymes TERM 7
DEFINITION 7 inactivates CYP 3A4 which increases the plasma levels of a wide variety of drugs that can lead to toxicitygood example of a food-drug adverse drug interaction TERM 8
DEFINITION 8 widely used antifungal drugpotent inhibitor of CYP enzymes which can lead to increased plasma levels of dozens ofdifferentdrugs TERM 9
DEFINITION 9 induce some CYP and inhibits other CYP TERM 10
DEFINITION 10 fast acting muscle relaxant which requires acetylcholine esterase (AchE) for biotransformationgenetic polymorphisms in AchE can result in prolonged drug induced apnea