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Biomedical Engineering Graduate Concentrations, Slides of Fluid Mechanics

classic engineering mechanics, physiology and cell biology, and the interface between the two. Biomechanics also has important applications in cutting-edge ...

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Revised: July 2021 Page 1
Biomedical Engineering Graduate Concentrations
Bioelectrics and Neural Engineering: Bioelectricity is the study of electrical fields and potentials within the body.
In the bioelectrical concentration students learn how to examine and control these fields towards developing medical
devices and restorative therapies. The core classes within this concentration focus on 1) examining nerve and cardiac
bioelectrical fields from a computational standpoint and 2) understanding techniques to model neurons and to
stimulate and record from individual and large populations of neurons. Electives within this concentration include
courses on medical imaging, systems-level neuroscience, and introductions to microelectronics and signal
processing. Students graduating from BME with a bioelectrical concentration will be able to work as engineers in
the rapidly expanding fields of neural engineering, medical diagnostics, and medical systems industries, or pursue
advanced degrees in medicine, basic medical sciences, or bioelectrical engineering. Advisor: Prof. Cindy Chestek
Biomaterials and Regenerative Medicine: Biomaterials is the study of interactions between living and non-living
materials. Students trained in biomaterials must have a thorough understanding of the materials they work with and
properties of the biological system they seek to replace or regenerate. Biomaterials are also an integral component
in tissue engineering and regenerative medicine. Biomaterials research areas include: design of orthopaedic, dental,
cardiovascular and neuro-sensory prostheses, artificial organs, blood-surface interactions, cellular and tissue
engineering, drug delivery, biosensors, microencapsulation technology, and implant retrieval analysis. Students
graduating from BME with a concentration in biomaterials will be capable of working in the medical device, tissue
engineering or pharmaceutical industries, academic or government laboratories, or pursuing further education in
Ph.D. or professional programs. Advisor: Prof. David Kohn
Biomechanics and Biotransport: Biomechanics is a hybrid discipline requiring a thorough understanding of
classic engineering mechanics, physiology and cell biology, and the interface between the two. Biomechanics also
has important applications in cutting-edge fields like tissue engineering and mechanotransduction. In tissue
engineering, one tries to regenerate new tissues to replace defects in existing tissue. This requires knowledge of
tissue-mechanical function. Mechanotransduction is the study of how cells sense and react to mechanical stimulus,
a field with applications in such diverse areas as hearing (haircell movement in fluids) and orthopaedics (bone and
tendon response to physical stress). Graduates in this concentration will be prepared for a wide range of industries
concerned with mechanical effects on the human body including surgical device industries, automotive safety, and
biotech industries concerned with mechanically functional tissue. Students will also have excellent preparation to
attend medical school or pursue a Ph.D. Advisor: Prof. David Kohn
Biomedical Imaging and Ultrasonics: Since the invention of x-ray computerized tomography more than 25 years
ago, imaging has become the primary noninvasive diagnostic tool available to the clinician. Although many
principles are common to all imaging modalities, biomedical imaging scientists and engineers must understand the
basic physics and operating principles of all primary modalities including magnetic resonance imaging (MRI),
radiography and nuclear medicine, optics, and ultrasound. Major biomedical imaging companies require such multi-
modality expertise to design new devices and procedures. In addition, clinical problems increasingly require the
techniques of cell and molecular biology to design both new contrast agents and imaging methods for a wider range
of applications. The biomedical imaging curriculum recognizes trends and requires students to have a solid
background in signal processing and imaging science, and simultaneously be literate in both the basic life sciences
and the basic operating principles of several imaging modalities. Graduates of this program will be well prepared
to work in the medical imaging industry, to attend medical school, or to study for a Ph.D. in BME. Advisor: Prof.
Xueding Wang
Biotechnology and Systems Biology: Advances in cellular and molecular biology have changed and expanded the
ways therapeutic devices and drugs are designed. Modern biotechnology depends on scientists and engineers who
study the fundamental properties of cell, molecular, and tissue biology, and apply these to engineer materials and
technology to interact with living systems. Goals include production of improved biomaterials for medical implants
and prosthetics, tissues engineered for specific functionality, and new therapeutic drugs. The biotechnology
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Biomedical Engineering Graduate Concentrations

Bioelectrics and Neural Engineering: Bioelectricity is the study of electrical fields and potentials within the body. In the bioelectrical concentration students learn how to examine and control these fields towards developing medical devices and restorative therapies. The core classes within this concentration focus on 1) examining nerve and cardiac bioelectrical fields from a computational standpoint and 2) understanding techniques to model neurons and to stimulate and record from individual and large populations of neurons. Electives within this concentration include courses on medical imaging, systems-level neuroscience, and introductions to microelectronics and signal processing. Students graduating from BME with a bioelectrical concentration will be able to work as engineers in the rapidly expanding fields of neural engineering, medical diagnostics, and medical systems industries, or pursue advanced degrees in medicine, basic medical sciences, or bioelectrical engineering. Advisor: Prof. Cindy Chestek Biomaterials and Regenerative Medicine: Biomaterials is the study of interactions between living and non-living materials. Students trained in biomaterials must have a thorough understanding of the materials they work with and properties of the biological system they seek to replace or regenerate. Biomaterials are also an integral component in tissue engineering and regenerative medicine. Biomaterials research areas include: design of orthopaedic, dental, cardiovascular and neuro-sensory prostheses, artificial organs, blood-surface interactions, cellular and tissue engineering, drug delivery, biosensors, microencapsulation technology, and implant retrieval analysis. Students graduating from BME with a concentration in biomaterials will be capable of working in the medical device, tissue engineering or pharmaceutical industries, academic or government laboratories, or pursuing further education in Ph.D. or professional programs. Advisor: Prof. David Kohn Biomechanics and Biotransport: Biomechanics is a hybrid discipline requiring a thorough understanding of classic engineering mechanics, physiology and cell biology, and the interface between the two. Biomechanics also has important applications in cutting-edge fields like tissue engineering and mechanotransduction. In tissue engineering, one tries to regenerate new tissues to replace defects in existing tissue. This requires knowledge of tissue-mechanical function. Mechanotransduction is the study of how cells sense and react to mechanical stimulus, a field with applications in such diverse areas as hearing (haircell movement in fluids) and orthopaedics (bone and tendon response to physical stress). Graduates in this concentration will be prepared for a wide range of industries concerned with mechanical effects on the human body including surgical device industries, automotive safety, and biotech industries concerned with mechanically functional tissue. Students will also have excellent preparation to attend medical school or pursue a Ph.D. Advisor: Prof. David Kohn Biomedical Imaging and Ultrasonics: Since the invention of x-ray computerized tomography more than 25 years ago, imaging has become the primary noninvasive diagnostic tool available to the clinician. Although many principles are common to all imaging modalities, biomedical imaging scientists and engineers must understand the basic physics and operating principles of all primary modalities including magnetic resonance imaging (MRI), radiography and nuclear medicine, optics, and ultrasound. Major biomedical imaging companies require such multi- modality expertise to design new devices and procedures. In addition, clinical problems increasingly require the techniques of cell and molecular biology to design both new contrast agents and imaging methods for a wider range of applications. The biomedical imaging curriculum recognizes trends and requires students to have a solid background in signal processing and imaging science, and simultaneously be literate in both the basic life sciences and the basic operating principles of several imaging modalities. Graduates of this program will be well prepared to work in the medical imaging industry, to attend medical school, or to study for a Ph.D. in BME. Advisor: Prof. Xueding Wang Biotechnology and Systems Biology: Advances in cellular and molecular biology have changed and expanded the ways therapeutic devices and drugs are designed. Modern biotechnology depends on scientists and engineers who study the fundamental properties of cell, molecular, and tissue biology, and apply these to engineer materials and technology to interact with living systems. Goals include production of improved biomaterials for medical implants and prosthetics, tissues engineered for specific functionality, and new therapeutic drugs. The biotechnology

curriculum emphasizes critical areas of chemistry, molecular biology, and cell biology, but also exposes students to a broad range of engineering approaches necessary for this interdisciplinary field. Graduates of this program will be well prepared for jobs in the pharmaceutical or medical device industries, to attend professional schools, or to study for a Ph.D. Advisor: Prof. Deepak Nagrath Medical Product Development: The design and development of medical devices and systems is unique in the way they are regulated and structured. Biomedical engineers can play key roles at all stages of medical product development, from needs finding and concept generation to design, prototyping, testing, fabrication, and commercialization. The goal of this concentration is to provide students with the practical knowledge and skills needed to bring new and improved devices to the clinic, in the context of the current healthcare environment. The core course is a two-semester design-build-test experience in which student teams work to solve real clinical problems in collaboration with practicing physicians. This experience is augmented with elective courses in regulatory affairs, quality systems, intellectual property, innovation, and other topics relevant to the development and commercialization of medical products. Graduates of this program will be well prepared for jobs in product development in a variety of medically-oriented industries, including biotechnology, pharmaceuticals, and medical devices. Advisor: Prof. Jan Stegemann SCHEMATIC OF COMPONENTS OF THE MASTERS COURSE CURRICULUM: CONCENTRATION CORE: Bioelectrics and Neural Engineering (at least one course): BIOMEDE 417 Electrical Biophysics (4) (I) BIOMEDE 517 Neural Engineering (3) (II) NOTE : Students who have previously taken an undergraduate bioelectricity course are advised to take BIOMEDE 517 instead of BIOMEDE 417.

Seminar and RCR

2 courses (seminars)

Mathematics

1 course

Life Sciences

1 course

Statistics

1 course

Concentration Core

1 course

à depth

Technical Electives

3 - 4 courses

à depth & breadth

Experiential

1 - 2 courses

à hands-on

Common to all

concentrations

Dependent on concentration

and student interest

Fig. 1 : General components of Masters curriculum in Biomedical Engineering.

MATHEMATICS (choose one course): Courses recommended for BME students: MATH 450 Advanced Mathematics for Engineers I (4) (I,II) MATH 454 Boundary Value Problems for Partial Differential Equations (3) (I,II,IIIa) MATH 463 Mathematical Modeling in Biology (3) (I) Course recommended for BME students following the Biomedical Imaging and Ultrasonics concentration: EECS 505 Computational Data Science and Machine (4) (I) EECS 551 Matrix Methods for Signal Processing (4) (I,II) Other courses with specialized content: MATH 462 Mathematical Models (3) (II) MATH 471 Introduction to Numerical Methods (3) (I,II,IIIb) MATH 540 Mathematics of Biological Networks (3) (I) MATH 550 Introduction to Adaptive Systems (3) (I) MATH 555 Introduction to Functions of a Complex Variable with Applications (3) (I,II) MATH 556 Applied Functional Analysis (3) (I) MATH 557 Applied Asymptotic Analysis (3) (II) MATH 558 Applied Nonlinear Dynamics (3) (I) MATH 559 Topics in Applied Mathematics (3) (varies) MATH 561 Linear Programming I (3) (I,II) MATH 562 Continuous Optimization Methods (3) (II) MATH 563 Advanced Mathematical Methods for the Biological Sciences (3) (II) MATH 564 Topics in Mathematical Biology (3) (II) MATH 568 Mathematical and Computational Neuroscience (3) (I) MATH 571 Numerical Linear Algebra (3) (I,II) MATH 572 Numerical Methods for Differential Equations (3) (II) MATH 651 Topics in Applied Mathematics: Modeling and Mechanics (3) (I) MATH 656 Introduction to Partial and Differential Equations (3) (I) MATH 657 Nonlinear Partial Differential Equations (3) (II) MATH 756 Advanced Topics in Partial Differential Equations (3) (II) MECHENG 501 Mathematical Methods in Mechanical Engineering (3) (I) MECHENG 564 Linear Systems Theory (4) (I,II) STATISTICS (choose one course): Course recommended for BME students: BIOMEDE 503 Statistical Methods for Biomedical Engineering (3) (II) Other courses with specialized content: BIOSTAT 602 Biostatistical Inference (4) (II) BIOSTAT 650 Applied Statistics I: Linear Regression (4) (I) BIOSTAT 651 Applied Statistics II: Extensions for Linear Regression (3) (II) EECS 501 Probability and Random Processes (4) (I,II) IOE 461 Quality Engineering Principles and Analysis (3) (I) STATS 470 Introduction to the Design of Experiments (4) (I) STATS 500 Statistical Learning I: Regression (3) (I) STATS 513 Regression and Data Analysis (3) (II) STATS 525 Probability Theory (3) (I)

NOTE : BME graduate students can only take EECS 501 in the winter term. LIFE SCIENCES (choose one course): Courses recommended for BME students: BIOMEDE 519 Quantitative Physiology (4) (I) BIOMEDE 599.009 Systems Biology of Human Diseases (3) (I) BIOMEDE 599.011 Engineering Approaches to Cancer Biology (3) (II) BIOLCHEM 515 Introductory Biochemistry (3) (I,II) CDB 530 Cell Biology (3) (I) CDB 550 Histology (4) (II) Other courses with specialized content: ANATOMY 403 Human Anatomy: Structure and Function (5) (I,II) ANATOMY 541 Mammalian Reproductive Physiology (4) (II) BIOLCHEM 451 Advanced Biochemistry: Macromolecular Structure and Function (4) (I) BIOPHYS 520 Methods of Biophysical Chemistry (3) (I) CANCBIO 554 The Science of Cancer (4) (II) CDB 581 Development Genetics (3) (I) CDB 583 Organogenesis: Stem Cells to Regenerative Biology (3) (II) KINESLGY 522 Clinical Neurophysiology and Neuroimaging (3) (varies) KINESLGY 545 Metabolic Responses to Exercise (3) (II) MCDB 422 Brain Development, Plasticity, and Circuits (3) (II) MCDB 423 Introduction to Research in Cellular and Molecular Neurobiology (3) (I,II) MCDB 427 Molecular Biology (4) (I,II) MCDB 428 Cell Biology (4) (I,II) MCDB 435 Intracellular Trafficking (3) (II) MICRBIOL 540 Human Immunology (3) (II) NEUROSCI 570 Human Neuroanatomy I (3) (I) NEUROSCI 601 Principles of Neuroscience I (3) (I) NEUROSCI 602 Principles of Neuroscience II (3) (II) PATH 581 Tissue, Cellular and Molecular Disease (3) (II) PHYSIOL 592 Integrated Neuroscience (2-4) (II) TECHNICAL ELECTIVES: Students must take sufficient technical elective credits to reach at least the 30 credits overall required for the MS degree. No more than 2 credits of seminar courses may be applied to the MS degree. NOTE : Students in any concentration may take one technical elective from the Medical Product Development list of technical electives (see Page 8). Bioelectrics and Neural Engineering BIOMEDE 510 Medical Imaging Laboratory (3) (II) BIOMEDE 516 Medical Imaging Systems (3) (I) BIOMEDE 517^1 Neural Engineering (3) (II) BIOMEDE 599.010 Current Topics in Neuromodulation (3) (II) EECS 414 Introduction to MEMS (4) (I) EECS 425 Integrated Microsystems Laboratory (4) (II) EECS 427^2 VLSI Design I (4) (I,II)

MECHENG 523 Computational Fluid Dynamics I (3) (I) MECHENG 524 Advanced Engineering Acoustics (3) (I) MECHENG 530 Advanced Heat Transfer (3) (II) MECHENG 617 Mechanics of Polymers II (3) (II) Technical electives with biomechanics content: BIOMEDE 534 Occupational Biomechanics (3) (II) MECHENG 599.006 Cellular Engineering (3) (II) Technical Electives with Connective Tissue Content: BIOMEDE 410 Design and Applications of Biomaterials (3) (I) HS 650 Data Science and Predictive Analytics (4) (I) MECHENG 505 Finite Element Methods in Mechanical Engineering & Applied Mechanics (3) (I) MECHENG 511 Solid Continua (3) (I) MECHENG 512 Theory of Elasticity (3) (II) MECHENG 517 Mechanics of Polymers I (3) (II) Technical Electives with Dynamics/Control Content: EECS 562 Nonlinear Systems & Control (3) (II) MECHENG 440 Intermediate Dynamics & Vibrations (4) (II) MECHENG 540 Intermediate Dynamics (3) (I) MECHENG 543 Analytical & Computational Dynamics I (3) (II) MECHENG 560 Modeling Dynamic Systems (3) (I) MECHENG 561 Design of Digital Control Systems (3) (II) Biotechnology and Systems Biology BIOMEDE 410 Design and Applications of Biomaterials (3) (I) BIOMEDE 456 Tissue Mechanics (3) (I) BIOMEDE 476 Biofluid Mechanics (4) (II) BIOMEDE 479 Biotransport (4) (II) BIOMEDE 504 Cellular Biotechnology (3) (II) BIOMEDE 561 Biological Micro- and Nanotechnology (3) (II) BIOMEDE 599.009 Systems Biology of Human Diseases (3) (I) BIOMEDE 599.011 Engineering Approaches to Cancer Biology (3) (II) BIOINF 527 Introduction to Bioinformatics and Computational Biology (4) (I) BIOLCHEM 660 Molecules of Life: Protein Structure, Function and Dynamics (3) (I) CANCBIO 554 The Science of Cancer (4) (II) CDB 550 Histology (4) (II) CHE 519 Pharmaceutical Engineering (3) (II) CHE 528 Reactor Engineering (3) (II) CHE 538 Statistical and Irreversible Thermodynamics (3) (I) CHE 542 Intermediate Transport Phenomena (3) (II) CHE 696 Selected Topics (3) (I,II) EECS 414 Introduction to MEMS (4) (I) HS 650 Data Science and Predictive Analytics (4) (I) MCDB 611 Neurochemistry/Neuropharmacology (1) (I) MECHENG 553 Microelectromechanical Systems (3) (I) MECHENG 599.006 Cellular Engineering (3) (II)

Medical Product Development NOTE : Students in any concentration may take one class from the following list as a technical elective. BIOMEDE 499.002 Clinical Observation and Needs Finding (2) (I) BIOMEDE 504 Cellular Biotechnology (3) (II) BIOMEDE 523 Business of Biology (2.25) (I) ARTDES 652 Design in the 21st^ Century BA523 Comprehensive Healthcare Strategies BE 608 Health Care Markets and Public Policies (1.5) (I) BIOINF 622 Translational Research (2) (I) CHE 517 Biopharmaceutical Engineering (3) (II) ENTR 500 An Introduction to Innovation: Tools for Career Success (3) (I) ENTR 520 Technology-Inspired Business Models (3) (I) ENTR 530 Innovation & IP Strategy (3) (I) ENTR 540 Business Math for Innovators (1.5) (II) ENTR 550 Interpersonal Skills: Leveling Up to Leadership (3) (I) ENTR 5 60 Project Management and Consulting (3) (I,II) ES 512 Business Basics for Graduate Engineers (3) (II) ES 720 Commercialization of Biomedicine (1.5) (II) HS 650 Data Science and Predictive Analytics (4) (I) IOE 461 Quality Engineering Principles IOE 491.083 Leadership in the Digital Age (2) (I) IOE 561 Risk Analysis IOE 570 Design of Experiments MECHENG 599 .003 Additive Manufacturing Theory and Practice (3) (II) KEY AND ADDITIONAL NOTES: Course Department & Number Course Name (# of credits) (term offered) Terms: I - fall, II - winter, III - spring-summer, IIIa - spring half, IIIb - summer half Students are responsible for checking the Office of the Registrar’s Schedule of Classes to ensure that their selected courses are offered and fit their schedule. Courses with 499/599 designation are in pilot phase and may not be offered in the term indicated.