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The 2nd OA Readiness Check is designed to give you additional practice
with new assessment-style questions to help prepare for success on the OA.
Thus, please try to mimic exam-like conditions by taking the test in one <
hr sitting without any study aids apart from your whiteboard/scrap paper.
Note: You can take the 2nd OA Readiness Check again if you're so
inclined, but you can not edit your response as you may have done with
the topic questions. You will be able to see the results afterwards.
1. What is the complementary sequence to 3’ ATG CGA ATA 5’? *
3’ TAT TCG CAT 5’
3’ TAC GCT TAT 5’
3’ GAT AGC ATA 5’
5’ ATA AGC GTA 3’
2. Which amino acid sequence would result from this Coding DNA
strand? 3’ ATG CAG ATA 5’? *
Feedback The correct answer is 3' TAT TCG CAT 5'. Remember complementary means “Matching or Pairing” You have to remember to pay attention to your numbers as well as your letters (A-T, G-C, 5'-3'). The correct answer is 3’ ATG CGA ATA 5’ (original sequence) 5’ TAC GCT TAT 3’ (complementary sequence) But we asked for it in the 3’ direction, so mirror answer to give correct answer: 3’ TAT TCG CAT 5’
Tyr Val
TyrIle Gln
Ile Ile Asp
Val
Leu His Lys
3. Which amino acid sequence would be made from this template
DNA strand? 5’ TAT TAC CGA 3’? *
Feedback The correct answer is Ile Asp Val. We are starting at the coding strand, and have to remember the relationship between coding DNA and mRNA. These two strands are non-complementary and parallel. So we copy the coding strand , change T ---> U, and then write the mRNA sequence: 3’ ATG CAG ATA 5’ coding 3’ AUG CAG AUA 5’ mRNA Mirror by changing orientation: 5’ AUA GAC GUA 3’ Read chart Ile Asp Val (chart is in direction of 5' ---> 3')
Acetyl CoA, RNA primer, DNA Ligase, Template phosphate
5. If you had a mother who is homozygous for a recessive disease,and
a father who is a heterozygous carrier, what percentage of children will
have the disease? *
6. Which of the following would represent a silent mutation if this is the
original sequence: 5’ AUC GUA ACA 3’? *
Feedback The correct answer is c 50% Homozygous recessive: aa Heterozygous: Aa Feedback The correct answer is b
5’ AUC GGA ACA 3’
5’ AUA GUA ACA 3’
5’ AUC GUA UAA 3’
5’ AUC CUC ACA 3’
7. If the original coding sequence is 5’ CGA TAC TTC AGA 3’ and it is
mutated to 5' CGA TAT TTC AGA 3', what type of mutation would have
taken place? *
Feedback The correct answer is B AUC GUA ACA Ile Val Thr Ile Gly Thr Missense Ile Val Thr Ile Val STOP nonsense Ile Leu Thr Missense
Feedback The correct answer is D
and other brain functions. Decreased expression of the MECP2 gene
causes Rett syndrome. Which of the following scenarios correctly
describes how Rett syndrome could be developed? *
A DNA-binding protein blocks RNA Polymerase from binding to the promoter
sequence, facilitating the transcription of the MECP2 gene.
Transcription factors are unable to bind to the transcription start site of the
MECP2 gene because nucleosomes are tightly packed together.
Transcription activators cause nucleosomes to separate, exposing the
MECP2gene.
RNA Polymerase binds to the MECP2 gene and begins translation.
11. Which of the following strands are complementary and anti-
parallel? *
Coding and Non-
templateTemplate and
mRNA
Coding and mRNA
Template and
tRNA
12. What is the correct order of the Central Dogma? *
Translation, Replication,
Transcription Transcription,
Replication, Translation Translation,
Transcription, Replication
Replication, Transcription,
Translation
Feedback The correct answer is B. The template and mRNA strands are complementary to each other. Feedback The answer is B. Gene expression is increased when nucleosomes are widely spaced and transcription factors and RNA Polymerase are able to bind to the transcription start site of the gene.
13. What happens when the incorrect base is added during the
synthesis of a DNA strand in DNA replication? *
agent. Of course I took her straight to the vet. What type of amino acid
bonds would be disrupted by exposure to the strong reducing agent? *
Hydrophobic
interactionsHydrogen
bonds Disulfide bonds
Ionic bonds
17. What type of bond can the amino acids below form to stabilize the
tertiary structure of a protein? *
Ionic bond
Hydrophobic
interactionHydrogen
bond
Disulfide bond
Feedback The correct answer are covalent (disulfide) bonds C
Feedback The correct answer is hydrogen bonds C
y
Tertiary
Quaternar
y
22. Which of the following is true about protein structure and
function? *
A protein has optimal function in its primary structure.
All proteins carry out cellular functions when they have obtained their final
quaternary structure.
Ionic bonds between the backbone groups of amino acids stabilize a
protein'stertiary structure.
The hydrophobic effect primarily contributes to a single subunit protein's
tertiary structure.
23. Glutamine is located at position 13, of a protein, and forms a hydrogen
bond with the amino acid at position 89. What would happenif the amino
acid at position 89 was mutated to alanine? *
Correct answer
The hydrophobic effect primarily contributes to a single subunit protein's
tertiary structure.
Feedback The correct answer is D. The hydrophobic effect drives the formation of the core of a protein, which is the predominant contributing factor to the protein's tertiary structure. Feedback Secondary structure B is the correct answer. Primary and secondary structures involve interactions between the backbones, tertiary and quaternary structures involve interactions between the variable groups
d
Feedback Answer is D peptide bonds
Peptide
26. Which pair of amino acids below could bond together to stabilizethe
tertiary structure of a protein? *
Option 1
Option 2
