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The importance of crystal production for structural investigations and the role of Creative Biostructure in providing crystallization screening services. The document also highlights the advantages of crystalline formulations over amorphous ones and the various crystallization techniques used by Creative Biostructure, including vapor diffusion and batch crystallization.
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Growth of high-quality crystals is a major obstacle in many structural
investigations. In recent years, the techniques for screening crystals
have improved dramatically. Creative Biostructure is pioneer in the
field of crystals screening, such as peptide crystallization and has led
many successful campaigns to produce the crystals in small and large
scale.
Creative Biostructure provides crystallization screening using a series of
crystallization techniques from vapor diffusion to microbatch screening.
Initial screening is conducted on a small scale using different vapor
diffusion techniques (sitting drop, hanging drop, sandwich drop, and
capillary) and batch crystallization techniques (slow evaporation, fast
evaporation, and anti-solvent precipitation). The crystallization
conditions will be further optimized and scaled up. The batch
crystallization process can be applied to both small and large scale
purification.
Reference
IvanRayment. (2002) Small-Scale Batch Crystallization of Proteins
Revisited: An Underutilized Way to Grow Large Protein
Crystals. Structure. Pages 147-151.