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Antiviral Drugs in Virology: Study Questions for Lecture 21, Exams of Human Resource Management

Gandhi Institute of Technology and ManagementHuman Resource Management

Study questions for a lecture on antiviral drugs in the context of virology. Topics covered include reasons for the limited number of antiviral drugs, mechanisms of action for nucleoside analog antiviral drugs, and the emergence of antiviral drug resistance.

Typology: Exams

2012/2013

Uploaded on 07/25/2013

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Virology(–(Biology(W3310
Study(Questions(for(Lecture(21(–(Antiviral(drugs(
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1.&What&are&the&reasons&why&there&are&so&few&antiviral&drugs?&Why&are&there&so&many&for&HIV?&
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2.&Why&can’t&we&isolate&a&drug&that&blocks&the&production&of&HIV&genomes&from&the&provirus?!!
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3.&How&do&nucleoside&analog&antiviral&drugs&work?&Why&does&the&drug&acyclovir&have&fewer&side&
effects&than&AZT?&
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4.&How&does&antiviral&drug&resistance&occur?&Is&drug&resistance&more&frequent&among&RNA&or&
DNA&viruses?&Why?&
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5.&You&are&taking&an&antiviral&for&AIDS&and&one&week&you&feel&badly&and&stop&taking&your&
medication.&What&might&happen&to&the&viruses&replicating&in&you&when&you&resume&antivirals?&
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6.&Why&is&resistance&to&Tamiflu&widespread&but&not&resistance&to&Relenza?&
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7.&Describe&one&mechanism&by&which&viruses&become&resistant&to&a&specific&antiviral.&
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8.&What&is&HAART&and&why&has&it&revolutionized&AIDS&therapy?&
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Virology – Biology W3310Study Questions for Lecture 21 – Antiviral drugs

  1. What are the reasons why there are so few antiviral drugs? Why are there so many for HIV?
  2. Why can’t we isolate a drug that blocks the production of HIV genomes from the provirus?
  3. How do nucleoside analog antiviral drugs work? Why does the drug acyclovir have fewer sideeffects than AZT?
  4. How does antiviral drug resistance occur? Is drug resistance more frequent among RNA orDNA viruses? Why?
  5. You are taking an antiviral for AIDS and one week you feel badly and stop taking yourmedication. What might happen to the viruses replicating in you when you resume antivirals?
  6. Why is resistance to Tamiflu widespread but not resistance to Relenza?
  7. Describe one mechanism by which viruses become resistant to a specific antiviral.
  8. What is HAART and why has it revolutionized AIDS therapy?

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