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A quantitative review of studies examining the relationship between alexithymia and medically unexplained symptoms (MUS) in children. The paper highlights the findings of seven out of eight studies that found higher levels of self-reported alexithymia in children with MUS compared to healthy controls. However, the results were inconsistent when comparing alexithymia in children with MUS and children with medical/psychiatric controls.
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Alexithymia in children with Medically Unexplained Symptoms: A systematic review Maria Hadji-Michael DClinPsych1,2* Eve McAllister DClinPsych1, Colin Reilly PhD1, Isobel Heyman FRCPsych1, Sophie Bennett PhD 1, *Corresponding author Affiliations (^1) UCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street London WC1N 1EH UK. (^2) Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK. (^3) Research Department, Young Epilepsy, Lingfield, Surrey, RH7 6PW, UK. Short Title: Alexithymia and Medically Unexplained Symptoms in children Corresponding Author: Maria.Hadji-Michael@gosh.nhs.uk Keywords: Alexithymia, Functional somatic illness, medically unexplained symptoms, children. Declarations of interest: none
Highlights Children with MUS have higher levels of Alexithymia than controls on survey measures Higher rates of alexithymia were however, not found on task based measures Children with MUS and alexithymia are at significant risk for anxiety
Introduction Alexithymia derives from the Greek words λεξις and θυμος which mean “without words for emotions" [1]. Although alexithymia was traditionally defined as a difficulty in recognizing and describing one’s own emotions, evidence in adult populations suggests that alexithymia is also associated with interoceptive difficulties, such as difficulty counting one’s own heart beats [2], reduced awareness of physical arousal [3], reduced accuracy on tasks of muscular effort effort and reduced taste sensitivity [4]. Cognitive characteristics associated with MUS have also been suggested including: difficulty in discriminating between one emotion and another and in distinguishing somatic states from emotions; difficulty in communicating one’s own emotions to others; difficulties in flexible thinking; difficulties in social understanding; and an externally oriented cognitive style with a an avoidance of focus on inner experiences [5,6]. It has been hypothesised that alexithymia, particularly impairment in interoception, may be a risk factor for, or precipitate/maintain medically unexplained symptoms (MUS) [7,8]. Medically unexplained symptoms (MUS) are a heterogeneous group of physical symptoms not fully explained by a well- defined medical, psychiatric or somatic illness [9]. DSM- 5 classification has helpfully moved away from the need to have no medical explanation, to incorporating cases where distress and impairment is more severe than expected even when there is a defined underlying disease. However, nomenclature and classification in this field continues to be imperfect. Conversion disorder is also under this broad category; some individuals may have – for example – both epileptic and non-epileptic seizures, others are more entirely dissociative and fit less well under the somatic symptom disorder umbrella. MUS are common in childhood and can be persistent and disabling [10,11]. Prevalence rates varying depending on definition measurement and age range. Domènech-Llaberia found that 20% of Spanish preschoolers were affected [12] whilst Berntsson et al. found that MUS affected 2 0 % of 7 - 12 year olds [13]. Synonyms or related phenomena include ‘somatoform’, ’psychogenic’ and ‘functional’ symptoms. Symptoms commonly experienced by children include headache, functional neurological symptoms/conversion disorder (including non-epileptic events, sensory phenomena, motor phenomena), cognitive/psychiatric problems, fatigue, pain and gastro- intestinal complaints [14,15,16,11,17,18]. MUS often remain undetected and misunderstood and can lead to unnecessary and even harmful investigations being carried out [19]. In children as in adults, they are associated with significant symptoms of depression and anxiety [20,21]. MUS can also have a detrimental effect on school attendance [22] and impact on family functioning with increased anxiety, depression and decreased quality of life among parents of affected children [23]. A systematic review of the paediatric literature identified that psychological interventions are associated with a significant reduction in symptom load, disability and school absence and should be the treatment of choice for many of the young people experiencing medically unexplained symptoms [9]. There are several potential pathways by which alexithymia might influence symptom severity and treatment outcome for patients with MUS. These include limited ability of individuals with a high level of alexithymia to cope adaptively with stressful situations [24,25], which may contribute to high levels of psychological distress [26,27]. Additionally, individuals with high levels of alexithymia may become prone to functional symptoms because of a tendency to amplify, focus on and misinterpret the somatic sensations that accompany states of emotional arousal as well as other normal bodily sensations [27, 2 8]. A meta-analysis of 18 studies found a
significant positive correlation between somatisation and alexithymia in adults and a significant increase in the prevalence of alexithymia in those with MUS compared to healthy controls [29]. In summary, research has demonstrated a possible association between high levels of alexithymia and increased medically unexplained symptoms in adults. There is also some evidence to suggest that alexithymia is associated with poorer treatment outcome for both MUS and commonly co-occurring mental health disorders in adults. However, despite the high prevalence of MUS in children and young people, there have been no systematic reviews which have examined the relationship between alexithymia and MUS in this age group. The aim of this review was therefore to investigate associations between MUS and alexithymia in children and young people. Specific objectives were to determine how the relationship between MUS and alexithymia has been studied to date in the paediatric population, establish whether there is a consistent relationship between alexithymia and MUS in this group and to investigate the association between alexithymia and measures of psychological functioning. Method Systematic review methods were used in accordance with Cochrane guidelines [30]. Electronic searches EMBASE, MEDLINE, PsycINFO and CINAHL databases were searched from inception to 25th^ April
Figure 1: Search process for studies focussing on alexithymia in children with medically unexplained symptoms (MUS)
Eight studies compared alexithymia in groups of children who had been diagnosed with MUS versus control groups without MUS. MUS groups included children and young people experiencing: pain [33], tension-type headache [34,35], functional abdominal pain [36,37], headache and stomach-ache [38] and Chronic Fatigue Syndrome (CFS) [39]. The control groups included healthy controls in all studies but in some cases also included children with other medical/psychological difficulties or children who scored highly on a measure of somatic symptoms but without a specific diagnosis. Three studies used non-clinical samples of school children [ 40 ,41,42]. All studies employed a case-control design with the exception of Meade et al. [41] who used a cohort design to explore the relationship between alexithymia and child/parent reported health. Quality assessment Nine out of 10 studies were rated ‘moderate’ with respect to quality (see Appendix B). All studies had sample sizes that were representative of the population being studied, with the exception of one study [37], which was rated weakly due to poor take up of participants in the study and the high number of withdrawals/dropouts. Six of ten studies used well validated and reliable measures [36,40,33,38,37, 41 ) and so were rated strongly for data collection methods, whereas the four remaining used reliable measures but which have not yet been validated in child populations and therefore rated moderately [ 34 ,35, 42 , 39 ]. Measures Alexithymia Four studies used the Toronto Alexithymia Scale (TAS; 43 ,e.g. 33, 41 ,38,39] , two studies used the Alexithymia Questionnaire for Children (ACQ; 44, e.g.34,35] and two studies used the Emotion Awareness Questionnaire [EAQ; 36 ; 51 , 37 ]. All these measures are completed by the child. There is strong support for the generalizability of the three-factor structure of TAS across languages and cultures [45]. In addition, the full-scale TAS-20 and the first two factors show adequate to good internal reliability for most of the translations when used with children [e.g., 46]. Validation studies of the AQC [44) have identified the three-factor structure of alexithymia, although the factor Externally-Oriented Thinking showed low factor loadings and a low reliability. The predictive value of the questionnaire was also satisfactory. The measure has also been found to have good cross-cultural validity [47, 48]. The EAQ has also been found to have also has good predictive validity with respect to self-reported somatic complaints in children (in samples from two different countries, the UK and the Netherlands. This questionnaire has also been validated cross culturally [49]. A further study used only two of the subscales from the EAQ as part of their study together with children’s performance on an experimental task [ 40 ]. Two studies utilized non-standardized tests tapping into the emotional abilities of the child using the spontaneous attention to emotion task, identification of own emotions task or identification of an emotion in a mixed emotion situation. Medically Unexplained Symptoms A number of validated measures of medically unexplained symptoms were used (see Table 1 ) including the Children’s Somatization Inventory [41], the Somatic Complaint List [ 36 , 40 ], the
that children with more somatic complaints reported significantly more negative and less positive moods than those who reported less somatic complaints on a MOOD Questionnaire. Jellesma et al. [36] found that Children with FAP and children with more somatic complaints reported more negative moods on Anger, Sadness and Fear scale of the MQ and on the CDI compared to the control group with few somatic complaints. There was not a significant difference between the groups with respect to happiness. Discussion MUS in the pediatric population are distressing and impairing for children and their families, and represent a significant challenge to health service providers. Both patients and supporting health professionals often express frustration regarding diagnosis and treatment. Understanding more about the association between alexithymia and the development and maintenance of MUS and co-occurring conditions may help improve the assessment and treatment of children experiencing these difficulties. In this systematic review, we synthesized evidence from studies examining the relationship between alexithymia and medically unexplained symptoms in children. Higher levels of self-reported alexithymia in the children with MUS compared to healthy controls were found in the majority of studies but this finding was not replicated in studies where objective tasks measuring alexithymia were used. Results of studies comparing alexithymia in children with MUS and children with with medical/psychiatric controls were inconsistent. There is thus some evidence of increased emotional symptoms in children with MUS and alexithymia compared to controls but studies have employed a diverse range of methods of measuring alexithymia and emotional functioning making comparisons across studies difficulty. The current limited evidence does not allow firm conclusions to be drawn about the relationship between MUS and alexithymia in children and young people. The difference in results regarding the relationship between MUS and alexithymia between self- reported measures and task-based approaches noted in this review is important. The efficiency of self-report measures and the long-standing belief that self-report provided optimal access to one’s own psychological processes has kept self- report measures at the forefront in research on psychological functioning. Yet, self-report may be limiting particularly with respect to assessing alexithymia. There is the conceptual difficulty regarding the reporting of characteristics that by definition involve limited or impaired introspection, thus raising questions about the validity of this approach [52, 53 ]. Studies adopting task based methodology have not found a consistent association between MUS and difficulty in understanding one’s own emotions and these studies suggest that it is not a difficulty in understanding emotions per se that might be different between children with MUS and controls, but differences in emotion processing. It is possible that children have learned what emotional experience they or another person would/should have in a specific circumstance (emotional empathy), but not spontaneously recognise when they are feeling bodily symptoms associated with the specific emotion. Children with alexithymia would appear to be at significant risk of mental health symptoms in particular symptoms of anxiety based on results of the current review and several other studies previously conducted [ 54 ]. However, in the current review, not all studies included measure of emotional symptoms and measures varied across studies. Another factor not considered in the
studies concerns the validity of measures of self-reported mental health symptoms in this population. These measures may not be useful in detecting mental health problems in children with MUS [ 55 ] and thus professional clinical diagnoses are likely to be the gold standard in the MUS population. Future research and clinical implications The higher rates of alexithymia in children with MUS compared to healthy controls based on questionnaire measures found in this review may mean that evidence based psychological interventions to treat both the MUS and comorbid mental health difficulties may need to be adapted. Children with alexithymia may benefit from specific interventions such as body awareness training/ interoceptive training [ 56 ] to enhance engagement with, and response to, cognitive behavioural therapy, but studies are needed to examine this. Given that individuals with alexithymia may have difficulty recognising and reporting on their own emotions the use of experimental tasks for assessing alexithymia should be a priority in future research studies. Additionally as well as self and parent report of behavioural-emotional functioning the need for professional clinical assessment and diagnoses of mental health conditions should be a priority in research. All studies to date are cross-sectional and there is a need for longitudinal data to better understand the relationship between alexithymia and MUS over time. Studies of psychological interventions for MUS in children need to include measures of alexithymia to better understand factors which might contribute to outcome in this group. It will be important to assess whether levels of alexithymia change after treatment and what this might mean for prognosis. In adults there is evidence in patients with eating disorders that alexithymia improved following treatment [5 6 ] and it may be that psychological interventions change core symptoms but also impact on alexithymia. To date studies that have included measures of behavioural and emotional functioning have included only measures of depression and anxiety. There is also a need for future studies to include measures of autism spectrum disorder [5 7 ], attention deficit hyperactivity disorder and also neuropsychological assessment data which may be related to alexithymia. Finally, little is known about the developmental course of MUS and alexithymia; this requires more research to establish whether difficulties in childhood also play out in adulthood. Conclusion There is some evidence that children with MUS have significantly higher levels of alexithymia than healthy controls based on self-report measures however, this finding was not replicated in objective tests of alexithymia and measures have varied significantly across studies. Children with alexithymia have elevated rates of anxiety. Future studies which employ both self-report and task based measures of alexithymia and include measures of comorbid psychiatric and neuropsychological functioning are needed to better understand the possible role of alexithymia in paediatric MUS. Acknowledgements There was no external funding for this study. This research was supported by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for
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Table 1: Studies which have focussed on alexithymia in children with Medically Unexplained Symptoms (MUS) Year Author Study Design Sample N (females, age in years) Alexithymia measures
measures/diagn osis Mental Health Measures Main Findings 2015 Gatta et al. Case control
2011 Gatta et al. Case control