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A midterm exam or study guide for an advanced pathophysiology course. It covers a wide range of topics related to human physiology and disease processes, including thyroid disorders, adrenal gland disorders, cardiac conditions, and metabolic disorders like diabetic ketoacidosis. Definitions, explanations, and sample questions/answers related to these topics, which could be useful for students preparing for an exam or seeking to deepen their understanding of advanced pathophysiology concepts. The level of detail and technical terminology suggests this document is intended for university-level students, likely in a nursing or medical program.
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A runner has depleted all the oxygen available for muscle energy. Which of the following will facilitate his continued muscle performance? - Answer: Anaerobic glycolysis What causes the rapid change in the resting membrane potential that initiates an action potential? - Answer: Sodium gates open, and sodium rushes into the cell, changing the membrane potential from negative to positive. A 12-year-old male is diagnosed with Klinefelter syndrome. His karyotype would reveal which of the following? - Answer: XXY A nurse is reviewing the pedigree chart. When checking for a proband, what is the nurse looking for? - Answer: The person who is first diagnosed with a genetic disease An aide asks the nurse why people who have neurofibromatosis will show varying degrees of the disease. Which genetic principle should the nurse explain to the aide? - Answer: Expressivity In teaching a patient with cirrhosis, which information should the nurse include regarding cholesterol? - Answer: Cholesterol decreases the membrane fluidity of the erythrocyte, which reduces its ability to carry oxygen. When a patient asks what causes cystic fibrosis, how should the nurse respond? Cystic fibrosis is caused by an _____ gene - Answer: Autosomal recessive How are potassium and sodium transported across plasma membranes? - Answer: By adenosine triphosphate enzyme (ATPase) The nurse would be correct in identifying the predominant extracellular cation as: - Answer: Sodium The early dilation (swelling) of the cell's endoplasmic reticulum results in: - Answer: Reduced protein synthesis What principle should the nurse remember when trying to distinguish aging from diseases? - Answer: It is difficult to tell the difference because both processes are believed to result from cell injury.
What is the diagnosis of a 13-year-old female who has a karyotype that reveals an absent homologous X chromosome with only a single X chromosome present? Her features include a short stature, widely spaced nipples, reduced carrying angle at the elbow, and sparse body hair. - Answer: Turner syndrome A eukaryotic cell is undergoing DNA replication. In which region of the cell would most of the genetic information be contained? - Answer: Nucleolus The nurse is teaching staff about the most common cause of Down syndrome. What is the nurse describing? - Answer: Maternal nondisjunction A 50-year-old male was recently diagnosed with Huntington disease. Transmission of this disease is associated with: - Answer: Delayed age of onset A patient wants to know the risk factors for Down syndrome. What is the nurse's best response? - Answer: Pregnancy in women over age 35 What is the role of cytokines in cell reproduction? - Answer: Provide growth factor for tissue growth and development A newborn male is diagnosed with albinism based on skin, eye, and hair appearance. Which finding will support this diagnosis? - Answer: Inability to convert tyrosine to DOPA (3,4 dihydroxyphenylalanine) Sodium and water accumulation in an injured cell are a direct result of: - Answer: Decreased ATP production A nurse is reading a chart and sees the term oncotic pressure. The nurse recalls that oncotic pressure (colloid osmotic pressure) is determined by: - Answer: Plasma proteins The ion transporter that moves Na + and Ca 2+ simultaneously in the same direction is an example of which of the following types of transport? - Answer: Symport A 20-year-old pregnant female gives birth to a stillborn child. Autopsy reveals that the fetus has 92 chromosomes. What term may be on the autopsy report to describe this condition? - Answer: Tetraploidy Why is potassium able to diffuse easily in and out of cells? - Answer: Because the resting plasma membrane is more permeable to potassium Hypothyroidism - A disorder caused by a thyroid gland that is slower and less productive than normal, does not produce enough T3 and T
adrenal cortex - outer section of each adrenal gland; secretes cortisol, aldosterone, and sex hormones Aldosterone - Hormone that stimulates the kidney to retain sodium ions and water to regulate BP via angiotensin-aldosterone system, retention of sodium and secretes potassium cortisol - stress hormone released by the adrenal cortex helps the body deal with stress such as illness or injury increases blood glucose breaks down fats, proteins, carbs electrolyte regulations Negative feedback - Hypothalamus releases CRH corticotropin releasing hormone --> pituitary gland releases ATCH adrenocorticotropic hormone --> adrenal cortex to release cortisol increased - Cushings disease has ___ secretion of cortisol decreased - Addison's disease has __ secretion of cortisol and aldosterone Need to ADD some steroids syndrome - Cushing ___ is when an outside cause results in too much production of cortisol, like treatment with steroids disease - Cushings ___ is when an internal issue is causing over production of cortisol autoimmune - Addison's disease is typically an ____ disorder where the body is attacking the adrenal cortex on top of the adrenal gland Cushing's - ___ symptoms: skin fragile truncal obesity, small extremities with striae on them excessive hair "moon face"
buffalo hump females --> no menstruation males--> ED hyperglycemia d/t high cortisol Addison's - ___ symptoms: brownish hyperpigmentation of skin diarrhea, nausea hyponatremia d/t low aldosterone levels --> hyperkalemia hypoglycemia d/t low cortisol low bp, risk for vascular collapse going into shock Anti-diuretic hormone - aka Vasopressin ADH is a hormone made by the hypothalamus in the brain and stored in the posterior pituitary gland. It tells your kidneys how much water to conserve. ADH constantly regulates and balances the amount of water in your blood. increase - SIADH will have ___ in antidiuretic hormone decrease - Diabetes insipidus will have a __ in ADH posterior pituitary gland - stores and secretes ADH after hypothalamus produces ADH Pheochromocytoma - a benign tumor of the adrenal medulla that causes the gland to secrete catecholamines (epinephrine, norpinephrine, dopamine, and dopa) leading to high BP, headache, sweating and symptoms of a panic attack. diabetic ketoacidosis - acidity of the blood caused by the presence of ketone bodies produced when the body is unable to burn sugar; thus, it must burn fat (triglycerides and amino acids instead of glucose) for energy hyperglycemia hyperketonemia
mitral insufficiency; incompetent mitral valve allows regurgitation of blood from the left ventricle back into left atrium during systole mitral stenosis - narrowing of the mitral valve orifice that impedes blood flow from the left atrium to the left vetricle mitral valve prolapse - Improper closure of the valve between the heart's upper and lower left chambers. billowing of mitral valve leaflets into the left atrium during systole pulmonic regurgitation - pulmonic insufficiency; backflow of blood through incompetent pulmonic valve into the right ventricle causes blood from from the pulmonary artery into the right ventricle during diastole pulmonic stenosis - narrowing of the opening and valvular area between the pulmonary artery and right ventricle narrowing of the pulmonary outflow tract causing obstruction of blood flow from the right ventricle to the pulmonary artery during systole deep vein thrombosis - blood clot forms in a large vein, usually in a lower limb d/t impaired venous return, endothelial injury or hypercoagulability thrombi - __ consist of thrombin, fibrin, and red blood cells with few platelets and without treatment can travel to the lungs causing PE Hypertension - high blood pressure sustained SBP > BP= cardiac output x total peripheral vascular resistance (TPR) HTN leads to ↑ CO, ↑ TPR