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7.2 Amines as bases.
Amines are weak bases, like ammonia:
Ammonia: NH 3 + H 2 O < ___^ > NH 4 +^ + OH-
+ OH-
+ H-O-H < ___^ >
Amines undergo neutralization reactions with acids to form alkylammonium ions
a) CH 3 NH 2 + HCl <____^ > CH 3 NH 3 +^ Cl -
Methylamine hydrochloric acid methylammonium chloride
b) dimethylamine + H+^ < ___^ > dimethylammonium ion
www.answers.com/topic/ammonium
Write the equation for the neutralization of trimethylamine with HCl
A molecule with two amine groups can react with two molecules of HCl or other acid.
NH 2 (CH 2 ) 4 NH 2 + 2 HCl <____^ > Cl -1^ +^ NH 3 (CH 2 ) 4 NH 3 +^ Cl -
Neutralization of an amine with a carboxylic acid at room temperature
Sample problem: Write the equation for the neutralization of acetic acid with dimethylamine.
+ ____^ > +
Dimethylammonium acetate
Practice problem: Write the equation for the neutralization of trimethylamine with formic acid.
This neutralization reaction can occur in amino acids within the same molecule:
Amine groups in Rings
N can also exist in rings such as the 6-membered ring piperidine. Even though it is frequently drawn flat, it has a conformation similar to cyclohexane.
really looks like NH
One example of a molecule containing the piperidine ring is piperine, the primary molecule responsible for giving black pepper its flavor.
drugs for the treatment of malaria. It was marketed for treating nocturnal leg cramps until 1994 before being banned by the FDA. It has a rather complex structure with multiple rings and several chiral centers. Label the chiral centers.
Quinine wikipedia.org/wiki/Image:Tonic_water_uv.jpg
