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40 Multiple Choice Questions on Fundamentals of Biochemistry | BCH 401G, Exams of Biology

University of Kentucky (UK)Biology

Prof. Rebecca Dutch

Material Type: Exam; Professor: Dutch; Class: FUNDAMENTALS OF BIOCHEM; Subject: Biochemistry; University: University of Kentucky; Term: Spring 2014;

Typology: Exams

2013/2014

Uploaded on 12/14/2014

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Exam 3 Biochemistry 401G Spring 2014

• Please place the letter for the answer that you select in the correct place on the automated

scoring sheet

• Please note that there are five possible answers for every question.

• Please answer all questions. There is no penalty for guessing.

Chapters 24-26

1. Phosphorolysis of glycogen by glycogen phosphorylase is energetically advantageous

because it releases:

A. glucose

B. UDP-glucose

C. fructose 6-phosphate

D. glucose 1- phosphate

E. glycerol 3-phosphate

2. Glucagon ________________glycogen degradation by binding to its 7-transmembrane

receptor in the _______________.

A. stimulates; liver

B. inhibits; liver

C. stimulates; muscle

D. inhibits; muscle

E. stimulates; brain

3. Which of the following statements about glycogen degradation is FALSE?

A. Glycogen phosphorylase hydrolyzes α-1, 4-glycosidic bonds.

B. Hydrolysis of the α−1, 6-glycosidic bonds by the debranching enzyme yields glucose.

C. Glycogen degradation in liver is important for maintaining normal blood glucose

levels.

D. Muscle glycogen phosphorylase b is allosterically activated by high levels of AMP.

E. Activated phosphorylase kinase inhibits glycogen degradation by phosphorylating

protein kinase A.

4. Glycogen formation by glycogen synthase requires __________________, which is an

activated form of glucose.

A. glucose pyrophosphate

B. glucose 1,6-bisphosphate

C. UDP-glucose

D. glycosyl-CoA

E. CTP-glucosamine

Partial preview of the text

Download 40 Multiple Choice Questions on Fundamentals of Biochemistry | BCH 401G and more Exams Biology in PDF only on Docsity!

Exam 3 Biochemistry 401G Spring 2014

Please place the letter for the answer that you select in the correct place on the automated scoring sheet
Please note that there are five possible answers for every question.
Please answer all questions. There is no penalty for guessing. Chapters 24- 26

Phosphorolysis of glycogen by glycogen phosphorylase is energetically advantageous because it releases: A. glucose B. UDP-glucose C. fructose 6-phosphate D. glucose 1- phosphate E. glycerol 3-phosphate
Glucagon ________________glycogen degradation by binding to its 7-transmembrane receptor in the _______________. A. stimulates; liver B. inhibits; liver C. stimulates; muscle D. inhibits; muscle E. stimulates; brain
Which of the following statements about glycogen degradation is FALSE? A. Glycogen phosphorylase hydrolyzes α-1, 4-glycosidic bonds. B. Hydrolysis of the α−1, 6-glycosidic bonds by the debranching enzyme yields glucose. C. Glycogen degradation in liver is important for maintaining normal blood glucose levels. D. Muscle glycogen phosphorylase b is allosterically activated by high levels of AMP. E. Activated phosphorylase kinase inhibits glycogen degradation by phosphorylating protein kinase A.
Glycogen formation by glycogen synthase requires __________________, which is an activated form of glucose. A. glucose pyrophosphate B. glucose 1,6-bisphosphate C. UDP-glucose D. glycosyl-CoA E. CTP-glucosamine

Which statement about glycogen metabolism is CORRECT? A. Protein phosphatase 1 (PP1) activates glycogen degradation by dephosphorylating protein kinase A. B. Glycogen degradation in muscle is stimulated by high levels of glucose 6-phosphate and ATP. C. Insulin stimulates glycogen degradation by preventing the phosphorylation of glycogen phosphorylase. D. Glycogen synthesis requires a primer that is synthesized by glycogenin. E. Glycogen synthase is activated by phosphorylation when lactate is abundant.
The enzymes listed below are involved in glycogen metabolism. Which of these enzymes is activated in the resting muscle. A. protein kinase A B. phosphorylase kinase C. glycogen phosphorylase D. protein phosphatase 1 E. None of the above.
Von Gierke disease or type I glycogen storage disease is caused by a lack of ______________in the liver and results in __________________. A. glycogen phosphorylase; ketosis B. glucose 6-phosphatase; hypoglycemia C. branching enzyme; hyperglycemia D. glycogen synthase; hypoglycemia E. debranching enzyme; hyperglycemia
The primary substrate for the pentose phosphate pathway is: A. glucose 6-phosphate B. glucose 1-phosphate. C. UDP-glucose. D. fructose 1,6-bisphosphate E. acetyl CoA
The pentose phosphate pathway operates in four distinct modes. When the need for ribose 5 - phosphate exceeds the need for NADPH, then pentose phosphate pathway operates in Mode 1 , which involves: A. oxidative phase only. B. non-oxidative phase only. C. oxidative phase → non-oxidative phase → gluconeogenesis. D. oxidative phase → non-oxidative phase → glycolysis. E. non-oxidative phase → citric acid cycle.

Which of the following statements about sphingolipids is FALSE? A. Sphingosine is synthesized from diacylglycerol by attachment of an alcohol. B. The sphingosine backbone contains 18 carbons. C. Ceramide is the initial product of the sphingosine biosynthetic pathway. D. Formation of sphingolipids requires the substitution of the terminal hydroxyl group of ceramide. E. Sphingolipids are important membrane lipids found in all eukaryotic cells.
The formation of ________________is the committed step in cholesterol biosynthesis. A. malonyl CoA B. citrate C. mevalonate D. phosphatide E. β-hydroxybutyrate
Familial hypercholesterolemia is caused by loss of: A. HDL. B. LDL receptor. C. gangliosides. D. carnitine acyl transferase I. E. dipalmitoyl phosphatidylcholine. Chapters 30- 33
A 58-year old man is awoken with lots of pain in his joints. He is diagnosed with gout. Inhibition of which of the following enzymes might prevent the occurrence of such symptoms? A. Amido trasferase B. PRPP synthetase C. Xanthine oxidase D. Orotate phosphoribosyl transferase E. Carbomoyl phosphate synthestase II
Which of the following is a required substrate for purine biosynthesis? A. 5 - methyl-thymidine B. Ara-C C. Ribose phosphate D. PRPP E. 5 - fluor uracil

The urea cycle takes place in _______. A. the mitochondria B. the cytosol C. both the mitochondria and cytosol D. the lysosomes E. the nucleus
The two nitrogens of urea are derived from which of the following? A. aspartate and ammonia B. glutamate and ammonia C. alanine and ammonia D. argino-succinate and glutamine E. valine and glutamine
What are the four processes in the nitrogen cycle? A. ammonification, nitrogen fixation, amino acid catabolism and nitrification B. amino acid synthesis, nitrogen fixation, denitrification and amino acid catabolism C. denitrification, nitrogen fixation, urea cycle and nitrogen cycle. D. Transamination, nitrification, urea cycle and deamination E. nitrogen fixation, nitrification, ammonification and denitrification
Starting with free ammonium ion and the carbamoyl phosphate synthetase reaction, which of the following is CORRECT about the urea cycle? A. carbamoyl phosphate is synthesized in the cytosol B. the nitrogen from aspartate is added to citrulline in the mitochondria C. arginase produces urea in the mitochondria D. ornithine is converted to citrulline in the mitochondria E. aspartate is added to arginosuccinate in the mitochondria
A segment of DNA has one strand with the following sequence of bases:

5’-AGCGCATAGCAA-3’

Which of the following represents the complimentary strand of DNA?

A. 5’-UCGCGUAUCGUU-3’

B. 5’-TTGCTATGCGCT-3’

C. 5’-GAUAUGCGAUGG-3’

D. 5’-CTATACGCTACC-3’

E. 5’-AGCGCATAGCAA-3’

The following nitrogenous base is ________? A. cytosine B. thymine C. adenine D. uracil E. guanine
A nucleotide consists of which of the following? A. sugar and base B. base and phosphate C. pentose and base D. DNA, base and sugar E. sugar, base and phosphate
Chromosomes must condense to approximately 1/500th of their length for cell division. The first reduction is __________? A. looping of solenoid fibers to form a 300 nm fiber B. looping of 300 nm fibers C. coiling around nucleosomes D. forming a coiled solenoid fiber E. supercoiling of DNA
Which of the following statements about histones is TRUE? A. Most eukaryotic cells have six types of histone proteins. B. They interact with negatively charged sugar-phosphate backbone of DNA. C. They are a minor, but important enzymes. D. They are large acidic proteins with aspartate and glutamate resides. E. They bind to lipids.

Which of the following DNA sequences (only one strand is provided, you need to make the second strand) will be the most difficult to separate into single stranded molecules?

A. 5' GGGCTTTAATCGAAG 3'

B. 5' TTATATACGGCGTAG 3'

C. 5' GGCGGTACGCGTAGG 3'

D. 5' AATCTAGGCTTCATG 3'

E. 5 ’ TTCAGCAGCC 3 ’

Lucy is in search of her biological father. According to the restriction enzyme digestion analysis of her DNA (shown on the right), who is Lucy’s father? A. Peter B. Hans C. Tom D. Dan E. None of the above
Which of the following is an example of a transamination process? A. glutamate = hexanoic acid + NH 3 B. aspartate + hexanoic acid = glutamate + oxaloacetate C. glutamate = alpha-ketoglutarate + NH 3 D. tetrahydrofolate + glutamate = folic acid + methylene tetrahydrofolate E. aspartate + alpha-ketoglutarate = glutamate + oxaloacetate