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1.3 HEMATOLOGY: HYPOCHROMIC AND MICROCYTIC ANEMIAS QUESTIONS AND ANSWERS A+ REVIEW The osmotic fragility test result in a patient with thalassemia major would most likely be: A. Increased B. Decreased C. Normal D. Decreased after incubation at 37°C - ANS-✔✔B. Decreased B The osmotic fragility is decreased because numerous target cells are present and have increased surface volume in thalassemia major patients. All of the following are characteristic findings in a patient with iron deficiency anemia except: A. Microcytic, hypochromic red cell morphology B. Decreased serum iron and ferritin levels C. Decreased total iron-binding capacity (TIBC) D. Increased RBC protoporphyrin - ANS-✔✔C. Decreased total iron-binding capacity (TIBC) C In iron deficiency anemia (IDA), there is an increase in TIBC and in RBC protoporphyrin. The serum iron and ferritin levels are decreased. IDA is characterized by a microcytic hypochromic anemia.
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